THUMB BASE ARTHRITIS

The thumb base joint is one of the most remarkably complex but beautifully elegant joints in the body. It’s also the third most common joint affected by arthritis.

The InDx implant is the only implant that can fully mimic the natural but complex motions of the thumb joint. The device is also easier to insert and less invasive than any currently available surgical treatment option for this condition.

The InDx device accommodates the full range of thumb joint motions by providing two points of rotation that can move both concurrently and independently of each other, while enabling the joint to move in at least six degrees of freedom. This will provide an excellent clinical outcome and decrease the risk of surgical and clinical complications.

The InDx device offers an exciting new, patient sensitive treatment option to patients and surgeons and has been designed in conjunction with three of the world’s leading hand surgeons ensuring all end-user requirements are met.

ANIMATION OF SURGICAL PROCEDURE

Loci Orthopaedics win Best Innovation/R&D Award

Galway Chamber of Commerce Business Awards. November 29th, 2019. Galway, Ireland.   Galway based Loci Orthopaedics, originators of the InDx CMC Implant and InDx Project coordinators won the Best Innovation/R&D Award, sponsored by EY, at the Galway Chamber of...

PROJECT KICK-OFF MEETING

Dublin, 23rd of July 2019

The Project Kick-off Meeting was held in Dublin on July 23rd 2019 attended by at least one representative from each partner organisation. At this meeting, a presentation given by project coordinators, Loci Orthopaedics, outlined the responsibilities of each partner with regard to:

  • Work Packages, Tasks and Deliverables
  • Reporting requirements (both Technical and Financial) and the reporting process
  • Financial Management
  • Project Governance
  • Dissemination and Communication Strategy

PROGRESS TO DATE

Progress towards the project objectives to date

Monthly project meetings have been held since the Kick-off Meeting in order to report internally on progress towards the objectives for each task, identify and mitigate against any anticipated risks, and ensure good communication between partners.

Loci have worked with EndoLab for preliminary performance testing of the device which has shown excellent early results. The clinical investigation protocol for a First in Human Clinical Study is currently being developed by Loci and NAMSA. Loci has developed Instrcutions for Use and Surgical Procedure documents. MedVie have set up Project Management procedures to ensure that the project work is conducted and reported upon in a timely manner as well as communicating the project through development of this website.

FIRST IN HUMAN TRIAL

The First in Human Trial will be conducted in KU Leuven Hospital, Belgium, after enrolling 10 patients with Class II and Class III Thumb Arthritis.

The InDx implant has been successfully tested in nineteen pre-clinical trials in which the implant has been repeatedly and reliably inserted into 45 human cadaveric hands with excellent post-implantation results. This success is the result of four years of research and development, experimental proof of concept, and technological validation. Loci Orthopaedics has worked with three of the world’s leading hand surgeon experts in the biomechanics and kinematics of the thumb base joint to ensure that the InDx implant exceeds the functionality and clinical efficacy of all the competitor implant options. The First in Human Trial will be overseen by Prof. Filip Stockmans at KU Hospital, Belgium.

PROF. FILIP STOCKMANS
PROF OF HAND SURGERY
KU LEUVEN

Prof Stockmans has numerous peer-reviewed journal articles and book chapters on hand and thumb base joint surgery. He is one of the most prolific thumb base joint implant users in the world, with the best clinical outcomes recorded and studied of any European hand surgeon.

Loci Orthopaedics and EndoLab give a poster presentation at FESSH 2020 Virtual Congress

September 4th, 2020.

InDx Project coordinators Loci Orthopaedics and project partner EndoLab presented a poster at FESSH ON(line) Week, a virtual version of the annual Congress of the Federation of European Societies for Surgery of the Hand (FESSH), held in conjunction with the European Federation of Societies for Hand Therapy (EFSHT).

The poster, titled “Considerations on the effects of ASTM F2003 accelerated aging on UHMWPE when Gamma irradiated in air”, outlines the findings of research work conducted during the course of the InDx Project to identify the optimal sterilisation method for ultra-high molecular weight polyethylene components while both adhering to mandated regulations and ensuring integrity of the component.

The publication highlights the collaborative effort of the InDx Project consortium to create and disseminate new knowledge at the highest international level.

Loci Orthopaedics feature in Orthopedic Design & Technology magazine

August 13th, 2019.

InDx Project coordinators, Loci Orthopaedics, featured in the key industry publication ODT (Orthopedic Design & Technology) Magazine

The article highlighted the successful granting of this Fast Track to Innovation project, the granting of the US patent for the core technology, and the company entering into a further IP licence with the National University of Ireland Galway. This press release strengthened the company’s position, and that of the consortium partners, as a leaders in innovation in the clinical field.

Orthopedic Design & Technology is an industry-leading publication, providing in-depth, high-quality coverage of the specialized field of orthopaedic product development and manufacturing, industry news, design trends, and up-to-date market data to over 7,500 subscribers.

Click on the link below to read the full article:

https://www.odtmag.com/contents/view_breaking-news/2019-08-13/loci-orthopaedics-awarded-28-million-grant/

Loci Orthopaedics win Best Innovation/R&D Award

Galway Chamber of Commerce Business Awards. November 29th, 2019. Galway, Ireland.   Galway based Loci Orthopaedics, originators of the InDx CMC Implant and InDx Project coordinators won the Best Innovation/R&D Award, sponsored by EY, at the Galway Chamber of...

COMMERCIALISATION AND EXPLOITATION 

Commercialisation activity regarding the InDx project.

Innovation management within the project will be directed towards ensuring an effective and fast product development. Our innovation cycle will support the launch of an innovative market oriented solution. A deep understanding of the market needs, industry constraints and regulatory/standards framework is necessary. Through effective innovation management, which will be performed under the guidance of Dr. Brendan Boland, who will perform the role of Innovation Manager in the project, it will be ensured that the development team is guided by feedback loops from fellow developers, end- users and marketing to fuel an innovation cycle that leads to exploitable project results.

Loci Orthopaedics win Best Innovation/R&D Award

Galway Chamber of Commerce Business Awards. November 29th, 2019. Galway, Ireland.   Galway based Loci Orthopaedics, originators of the InDx CMC Implant and InDx Project coordinators won the Best Innovation/R&D Award, sponsored by EY, at the Galway Chamber of...

DISSEMINATION AND COMMUNICATION

Recent events at which the InDx project featured.

Loci Orthopaedics win Best Innovation/R&D Award

Galway Chamber of Commerce Business Awards. November 29th, 2019. Galway, Ireland.   Galway based Loci Orthopaedics, originators of the InDx CMC Implant and InDx Project coordinators won the Best Innovation/R&D Award, sponsored by EY, at the Galway Chamber of...

CONTACT US

If you would more information about the InDx project, please send us an e-mail: info@indxproject.eu

10 + 11 =

Project Coordinator Contact Details:

LOCI ORTHOPAEDICS

No. 4 Business Innovation Centre, National University of Ireland Galway, Ireland.
H91 H2Y0

info@lociorthopaedics.com

Project Manager Contact Details:

MEDVIE LTD.

Marine Court Centre Malahide, Malahide, Co. Dublin,
Ireland.
K36 VK53

info@medvie.ie

Loci Orthopaedics

MedVie Ltd.